• Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment 

      Sylte, Ole Christian; Johansen, Jesper Solheim; Heinla, Indrek; Houwing, Danielle; Olivier, Jocelien D.A.; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
      Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various afective disorders during pregnancy. SSRIs cross the placenta and afect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the ofspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social ...
    • Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders 

      Singh, Katyayani; Jayaram, Mohan; Kaare, Maria; Leidmaa, Este; Jagomäe, Toomas; Heinla, Indrek; Hickey, Miriam A.; Kaasik, Allen; Schäfer, Michael K.; Innos, Jürgen; Lilleväli, Kersti; Philips, Mari-Anne; Vasar, Eero (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-01)
      Neuronal growth regulator 1 (NEGR1) belongs to the immunoglobulin (IgLON) superfamily of cell adhesion molecules involved in cortical layering. Recent functional and genomic studies implicate the role of NEGR1 in a wide spectrum of psychiatric disorders, such as major depression, schizophrenia and autism. Here, we investigated the impact of <i>Negr1</i> deficiency on brain morphology, neuronal ...
    • Rat ultrasonic vocalizations and novelty-induced social and non-social investigation behavior in a seminatural environment 

      Heinla, Indrek; Chu, Xi; Ågmo, Anders j; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
      Although rats are known to emit ultrasonic vocalizations (USVs), it remains unclear whether these calls serve an auditory communication purpose. For USVs to be part of communication, the vocal signals will need to be a transfer of information between two or more conspecifics, and with the possibility to induce changes in the behavior of the recipient. Therefore, the aim of our study was to investigate ...
    • Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure 

      Heinla, Indrek; Heijkoop, Roy; Houwing, Danielle; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-26)
      SSRIs are commonly used to treat pregnant women with depression. However, SSRIs can cross the placenta and affect the development of the fetus. The effects of perinatal SSRI exposure, and especially the effects on social behavior, are still incompletely documented. This study first aims to investigate whether rats show prosocial behavior in the form of consolation behavior. Secondly, it aims to ...